Analysis of Exogenous Endocrine-Disrupting Chemicals (Environmental Hormones)

What are exogenous endocrine-disrupting chemicals (environmental hormones)?

The official name of “environmental hormones” is “exogenous endocrine-disrupting chemicals (endocrine disruptors),” and is defined as “exogenous substances which affect the normal hormonal action in a living body of an animal when taken in the living body” (Ministry of the Environment, 1998).

The substances suspected to have the endocrine-disrupting effect are dioxins, PCB (polychlorinated biphenyl), pesticides, bisphenol A (raw material for plastics), nonylphenol (raw material for nonionic surface active agents), phthalates, etc. The Ministry of the Environment lists 65 substances as chemical substances suspected to have the endocrine-disrupting effect.

Most exogenous endocrine-disrupting chemicals are indicated as the substances subject to the PRTR Law.

Fig.

JFE-TEC received the order of the “Research of Actual Situation of Exogenous Endocrine-Disrupting Chemicals in Water Environments” which is the large-scale research implemented by the Environmental Agency for the first time in Japan, and provide high-quality data as a pioneer of the environmental hormone analysis.

Phthalates

Diethyl hexyl phthalate (DEHP)

- Substances subject to REACH regulation
- Substances subject to EU Council Directive Concerning Safety of Toys
- Substances subject to JIG-B level management
- Substances subject to Survey of Chemicals in the Environment (so-called Black Book)
- Chemical Substances Control Law (existing substances)
- Substances subject to SPEED’98
- Indoor environment guideline value

Two out of 14 items are phthalates.

Bisphenol A

Bisphenol A

- Regulated by Food Sanitation Law
- Chemical Substances Control Law (existing substances / chemical substances subject to type III monitoring)
- Tolerable Daily Intake (1993)0.05 mg/kg body weight / day
- Substances subject to Norwegian PoHS regulation

Specific examples

  • Environmental research and analysis of environmental atmosphere, river water, seawater, bottom sediments, soil, and aquatic organisms
  • Research and analysis of exhaust gas, drainage water, etc. according to the PRTR Law
  • Analysis of special samples of chemical products, wastes, etc.
  • Analysis for dioxins decomposition test

Research Papers/Materials

“Capturing Efficiency Test for Endocrine-disrupting Chemicals in Atmosphere” (15th Symposium on Environmental Chemistry, 2006, 6)
Kenji Otsuka, Kazumi Ito, Fuyuhiko Suzuki (JFE Techno-Research Corporation)

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